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Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing food intake Acting on appetite centres in the brain to decrease hunger signals Microdosing refers to the practice of using substantially lower doses of a medication than those typically prescribed for its licensed indications

Instead, mRNA expression is detected in myenteric ganglia in the intestinal mucosa, which are excitable by GLP-1 treatment ex vivo (64% synaptic and 36% after-hyperpolarizing types) (Figure 1 and Table 2)

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